2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor
  5. AT1 Receptor Isoform
  6. AT1 Receptor Inhibitor

AT1 Receptor Inhibitor

AT1 Receptor Inhibitors (6):

Cat. No. Product Name Effect Purity
  • HY-17005
    Olmesartan medoxomil
    		Inhibitor 98.95%
    Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
  • HY-116439
    Diisononyl phthalate
    		Inhibitor 98.0%
    Diisononyl phthalate (DINP) is an orally active polyvinyl chloride plasticizer and indirect food additive. Diisononyl phthalate activates the ACE/AT1R axis and inhibits the production of NO. Diisononyl phthalate reduces the expression of eNOS. Diisononyl phthalate induces increased blood pressure in mice. Diisononyl phthalate induces monocytic leukemia in rats. Diisononyl phthalate can be used in hypertension-related research.
  • HY-111616
    GSK1820795A
    		Inhibitor 99.80%
    GSK1820795A, as a telmisartan analog, is a selective hGPR132a antagonist. GSK1820795A blocks activation of yeast cells expressing hGPR132a by N-acylamides. GSK1820795A is also a angiotensin II antagonists and partial PPARγ agonists (compound 38).
  • HY-17005R
    Olmesartan medoxomil (Standard)
    		Inhibitor
    Olmesartan medoxomil (Standard) is the analytical standard of Olmesartan medoxomil. This product is intended for research and analytical applications. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
  • HY-17005S
    Olmesartan medoxomil-d6
    		Inhibitor
    Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
  • HY-108120
    L-162537
    		Inhibitor
    L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension.